Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulat- ing factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC

ator of angiogenesis. Science 1992; 258: 1798–1801. 9. Kocher AA et al. Myocardial homing and neovascularization by human bone marrow angioblasts is regulated by IL-8/Gro CXC chemokines. J Mol Cell Cardiol 2006; 40: 455–64. 10. Watanabe T et al. Endogenous interleukin-8 (IL-8) surge in granulocyte colony-stimulating factor-induced peripheral blood stem cell mobilization. Blood 1999; 93: 1157–63. 11. Reed M.J., Edelberg J.M.. Impaired angiogenesis in the aged. Sci Aging Knowledge Environ 2004; 2004: pe7. 12. Hoetzer GL et al. Aging, exercise, and endothelial progenitor cell clonogenic and migratory capacity in men. J Appl Physiol 2007; 102: 847–52. 13. Kushner EJ et al. Aging and endothelial progenitor cell telomere length in healthy men. Clin Chem Lab Med 2009; 47: 47–50. 14. Peichev M. et al. Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors. Blood 2000; 95: 952–958. 15. Minamino K et al. Macrophage colony-stimulating factor (MCSF), as well as granulocyte colony-stimulating factor (GCSF), accelerates neovascularization. Stem Cells 2005; 23: 347–54. 16. Kanellakis P et al. Granulocyte colony-stimulating factor and stem cell factor improve endogenous repair after myocardial infarction. Cardiovasc Res 2006; 70: 117–25. 17. Orlic D et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A 2001; 98: 10344–9. 18. Kang HJ et al. Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial. Lancet 2004; 363: 751–6. 19. Ince H et al. Preservation from left ventricular remodeling by front-integrated revascularization and stem cell liberation in evolving acute myocardial infarction by use of granulocyte-colony-stimulating factor (FIRSTLINE-AMI). Circulation 2005; 112: 3097–106. 20. Takahashi T et al. Ischemiaand cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med 1999; 5: 434–8. 21. Lehrke S et al. Aging impairs the beneficial effect of granulocyte colony-stimulating factor and stem cell factor on post-myocardial infarction remodeling. Circ Res 2006; 99: 553–60. 22. Dzau VJ et al. Therapeutic potential of endothelial progenitor cells in cardiovascular diseases. Hypertension 2005; 46: 7–18. 23. Pula G et al. Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures. Circ Res 2009; 104: 32–40. 24. Gnecchi M et al. Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res 2008; 103: 1204–19. 25. Strehlow J et al. Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation. Circulation 2003; 107: 3059–65. 26. Haas DW et al. MDR1 gene polymorphisms and phase 1 viral decay during HIV-1 infection: an adult AIDS Clinical Trials Group study. J Acquir Immune Defic Syndr 2003; 34: 295–8. 27. Fadini G.P. et al. Technical notes on endothelial progenitor cells: ways to escape from the knowledge plateau. Atherosclerosis 2008; 197: 496–503. 28. Hill J et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. New Engl J Med 2003; 348: 593–600. 29. Werner N et al. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 2005; 353: 999–1007.